If you've ever used a retinoid, you know what a toll it can take on your skin barrier if you're not extra careful. Unfortunately, I had to learn that lesson the hard way. I used tretinoin for years but paired it with the wrong moisturizer, and, well, let's just say I'm still paying the price. Ask any dermatologist, and they'll tell you tretinoin is one of the strongest retinoids available. It's recommended that those with dry, sensitive, or reactive skin use it cautiously and start slow. However, once you start to use tretinoin, you'll likely see some great results.
But repeat after me: Hydration is vital. I'd been using tretinoin for a while when I realized my moisture barrier wasn't in great shape, so I stopped using it to let my skin recover. While I recently reincorporated a gentle retinol into my routine, I'm taking it slow and flooding my sensitive skin with extra hydration via a rich moisturizer.
If you use tretinoin (or are thinking about starting) and need to know what moisturizer to pair with it, I've got you. I asked dermatologists to break down the benefits of tretinoin and share the moisturizer they'd recommend people of each skin type pair with it.
The Best Moisturizers to Use With Tretinoin, at a Glance
- Best Overall: Vanicream Daily Facial Moisturizer
- CeraVe Moisturizing Cream
- Dieux Skin Instant Angel Skin Restoring Moisturizer
- Skinfix Barrier+ Strengthening and Moisturizing Triple Lipid-Peptide Cream
- SkinCeuticals Triple Lipid Restore
The Best Moisturizers to Use With Tretinoin in 2025
1. Best Overall: Vanicream Daily Facial Moisturizer
"Vanicream is my go-to recommendation for those experiencing extreme skin sensitivity and reactivity to everything," says Marcus. "It's hypoallergenic, soothing, and gentle enough even for babies." Consider this the gold standard of gentle face creams.
2. CeraVe Moisturizing Cream
This skin barrier–restoring cream from CeraVe helps lock in essential moisture with ingredients like hyaluronic acid, ceramides, and petrolatum. It's great for mitigating the dryness and irritation that can come with using retinoids. This is a good option for dry skin, but may not work as well if you're dealing with active breakouts as it might be too occlusive.
3. Cetaphil Moisturizing Cream
Another great drugstore option is Cetaphil's Moisturizing Cream, which contains a blend of niacinamide, panthenol, and glycerin to help significantly improve moisture levels and barrier function within the skin.
4. Dieux Skin Instant Angel Skin Restoring Moisturizer
I'm a huge fan of Dieux's Deliverance Serum ($69), but this restoring moisturizer is just as good. It contains everything your skin barrier needs to heal, protect, and stay hydrated. Phytosterols, fatty acids, peptides, ceramides, and squalane help keep skin strong, resilient, and hydrated when using things like tretinoin.
5. Glow Recipe Plum Plump Moisturizer
This hyaluronic acid–rich moisturizer from Glow Recipe brightens and balances skin with plum, willow herb, and polyglutamic acid, a hydrating peptide. It's a great option for all skin types since the formula is noncomedogenic. It won't clog pores but can provide acne-prone skin with the rich moisture it needs when it's also being treated with a retinoid.
6. Skinfix Barrier+ Strengthening and Moisturizing Triple Lipid-Peptide Cream
If you have extremely dry skin but want to incorporate tretinoin into your routine, you'll definitely want to combat irritation with this rich cream from Skinfix. It contains active lipids, peptides, small-particle hyaluronic acid, and shea butter to coat the skin in soothing moisture.
7. Biossance Squalane + Omega Repair Deep Hydration Moisturizer
The Boissance Squalane + Omega Moisturizer strengthens and repairs the skin barrier with ceramides, fatty acids, squalane, and hyaluronic acid. It's great for combatting the flakiness, dryness, and irritation that can happen if you're a first-time tretinoin user.
8. SkinCeuticals Triple Lipid Restore
If your barrier isn't in great shape or you have extra-dry, mature skin, SkinCeuticals' heavy-duty moisturizer is the one to use. Although it is rich in lipids, cholesterol, and fatty acids, it can also be used on acne-prone skin, as it contains zero pore-clogging ingredients.
9. Saturday Skin Waterfall Glacier Water Cream
Since tretinoin can cause irritation, it's important to soothe your skin when possible. This moisturizer does just that. It's formulated with Alaska glacier water and Iceland moss to reduce redness and calm the skin.
10. Testament Beauty Damascena Rose De-Stress Moisturizer
This moisturizer has a super-lightweight, cooling texture, so it's basically a tall glass of water for parched skin. Ingredients like Damascena rose, chamomile extract, and probiotics make the skin feel bright, smooth, energized, and radiant.
11. Fresh Rose & Hyaluronic Acid Deep Hydration Moisturizer
Another rose-infused moisturizer, this one boosts skin hydration up to 72 hours. It uses Damask rose and a duo of hyaluronic acids to deliver multi-level hydration.
What Is Tretinoin?
Board-certified dermatologist Brendan Camp, MD, gave us the rundown on tretinoin. "Tretinoin is a topical retinoid medication," he says. "While it's first and foremost an acne medication, tretinoin is also used for treating the effects of photoaging, namely fine lines, wrinkles, and dark spots. Tretinoin can increase collagen production over time when used regularly. It also helps normalize skin cell turnover to address texture changes and prevent the formation of blackheads and whiteheads."
Tretinoin vs. Retinol
There's a difference between regular retinol and tretinoin, according to board-certified dermatologist and Maei MD founder Rebecca Marcus, MD. "Retinol must be converted to retinoic acid to have an effect as opposed to [tretinoin, which is] prescription-strength and exists as retinoic acid [already]," Marcus explains. "Since retinols need to be converted to retinoic acid, they can take longer to have an effect but are often less irritating on the skin. This can make them a little more tolerable than a prescription alternative."
How does tretinoin benefit the skin?
When used correctly, tretinoin can help with everything from uneven texture to acne, fine lines, and dark spots. Those with dry skin, however, might tolerate lotion formulas of tretinoin, such as the prescription brands Altreno and Arazlo, Marcus says. She also suggests slowly working your way up to daily use when using any form of retinoid.
How to Use Tretinoin
"Using tretinoin two or three nights a week is a good idea. Then work up to nightly applications as your skin gets used to it," she says. "Tretinoins—and, in fact, all retinoids—make skin more sun sensitive, so it's more important than ever to remember your daily sunscreen. Retinoids should not be used by pregnant people. They should be applied at night, not during the day, as they are not photostable and therefore their efficacy is decreased by UV rays."
This article was published at an earlier date and has since been updated.
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